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Drug: Atorvastatin
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Generic name: Rosuvastatin
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Crestor (rosuvastatin) is a prescription statin medicine for the reduction of LDL cholesterol and some other blood lipids.
In the U.S., Crestor comes in 5 mg, 10 mg, 20 mg, and 40 mg dosages. The current information will only cover 5 mg, 10 mg, and 20 mg dosages because of their popularity.
RxCroma provides an opportunity to view information on Crestor and rosuvastatin generics, compare dosages and prices, and buy rosuvastatin online with a valid prescription.
Prescription required: Crestor and rosuvastatin are prescription medications. Only order and take the strength prescribed for you by your healthcare professional.
Crestor is the brand name of rosuvastatin, which is a member of the statin drug category.
The mode of action of rosuvastatin involves inhibition of HMG-CoA reductase, which is an enzyme that facilitates the formation of cholesterol in the liver. The drug leads to increased removal of LDL cholesterol by the liver, resulting in decreased levels of LDL-C and total cholesterol. The drug may lead to decreased levels of triglycerides and increased HDL cholesterol levels.
Crestor may be used in combination with dietary management and exercise for the treatment of cholesterol in suitable patients.
Crestor is available in forms of:
➧ Rosuvastatin 5 mg
➧ Rosuvastatin 10 mg
➧ Rosuvastatin 2 mg
➧ Rosuvastatin 40 mg
The dosage of rosuvastatin depends on various individual characteristics of the patient.
Rosuvastatin uses include the treatment of specific cholesterol disorders and reduction of cardiovascular risk.
Doctors generally recommend Crestor to:
Reduce total cholesterol
Lower elevated LDL cholesterol
Help manage hypercholesterolemia
Lower triglycerides
Help slow the progression of atherosclerosis in some adults
Treat heterozygous familial hypercholesterolemia (HeFH)
Treat homozygous familial hypercholesterolemia (HoFH)
Treat hypertriglyceridemia in adults
Treat primary dysbetalipoproteinemia
Lower the risk of major cardiovascular events in most adults at elevated cardiovascular risk
Crestor is administered together with an appropriate diet and exercise, where necessary.
Rosuvastatin does not suit all patients with high cholesterol levels. Your doctor will determine the suitability of rosuvastatin considering your medical background, lab tests, heart risks, and other drugs that you might be taking.
An ideal rosuvastatin dosage is based on individual parameters. According to current prescribing information in the United States, the dosage for an adult patient ranges from 5 mg to 40 mg daily.
The initial dose may depend on the indication and individual characteristics. For example, the FDA label recommends starting Asian patients at 5 mg once daily and recommends a 5 mg starting dose, with a maximum of 10 mg daily, in patients with severe renal impairment who are not on hemodialysis.
Rosuvastatin 5 mg is the lowest available Crestor strength.
It may be prescribed where a smaller dose is necessary. It is recommended by the FDA that Crestor should be started at 5 mg once daily for Asians, since there is increased exposure to rosuvastatin in such individuals, as well as for patients with severe renal dysfunction who are not undergoing hemodialysis.
If the doctor prescribes 5 mg, you will find information on Crestor 5 mg and generic rosuvastatin from RxCroma.
The dosage of Rosuvastatin 10 mg falls within the normal dosage range in adults and is commonly used when this dosage is recommended for a particular purpose.
Various aspects are considered before choosing this dosage by your healthcare professional, including your LDL-C level and heart condition, among others.
Rosuvastatin 20 mg is within the adult dosage range, and physicians may prescribe this medicine when a greater LDL-C reduction is needed.
The dose of 20 mg is not automatically right just because it is a higher dose. The prescribed strength should reflect your individual treatment goals and medical circumstances.
The current U.S. labeling also includes special guidelines for dosage in Asian patients and patients with some degree of renal insufficiency.
Take Crestor according to your healthcare provider's instructions.
The typical regimen for taking Crestor is one pill per day. At present, the prescription information in the United States recommends that Crestor can be taken at any time of day, regardless of meals.
Four weeks after you begin your medication, your healthcare provider can evaluate your LDL-C levels and increase your dosage if necessary.
Never change your rosuvastatin dose without consulting a medical practitioner.
There is no strict rule for taking rosuvastatin either in the morning or evening.
Crestor is available for consumption at any time of the day as long as you adhere to your recommended schedule.
Select the best time to take rosuvastatin that suits your schedule to ensure you do not forget to take your drug on time.
Crestor can be taken with or without food.
Food does not actually change rosuvastatin exposure. You can take your prescribed dose as per the schedule recommended by your physician.
The active ingredient in Crestor is rosuvastatin. It is primarily supplied as rosuvastatin calcium.
The currently available branded Crestor formulation contains rosuvastatin 5 mg, 10 mg, 20 mg, or 40 mg.
Inactive ingredients in Crestor include:
Crospovidone
Hypromellose
Lactose monohydrate
Magnesium stearate
Microcrystalline cellulose
Red ferric oxide
Titanium dioxide
Triacetin
Tribasic calcium phosphate
Yellow ferric oxide
You must consider these inactive ingredients seriously if you have allergies, intolerances, or dietary restrictions. Check the product labeling or talk to your pharmacist if you have concerns about the medication.
Like other prescription medications, rosuvastatin also causes certain side effects. Several individuals take statins without major problems. However, it is important to understand possible adverse reactions.
The commonly reported adverse effects of Crestor include:
Nausea
Headache
Weakness
Asthenia
Myalgia
Constipation
If any of these side effects persist, become bothersome, or concern you, talk to a medical practitioner or visit a local clinic.
One of the major risks associated with statins is muscle injury.
Seek emergency medical assistance from your healthcare provider if you experience unusual symptoms like:
Muscle tenderness
Chronic Muscle pain
Muscle weakness
Unusual muscle fatigue
There is a chance of developing increased myopathy and rhabdomyolysis as the dose increases and when taking some particular drugs or suffering from other diseases.
Seek urgent medical attention if you develop symptoms that could indicate serious liver injury, such as yellowing of the skin or eyes or other significant symptoms.
Very rarely, patients have developed immune-mediated necrotizing myopathy after taking statins.
Crestor and muscle pain is a matter that must be considered while taking rosuvastatin.
Muscle pain may be mild in nature; however, muscle pain, tenderness, or weakness that cannot be explained or that is severe must be reported. Consult your physician if any of these are accompanied by fever, fatigue, or dark colored urine.
Do not stop prescribed treatment without discussing it with your doctor unless you are experiencing an emergency and have been instructed otherwise.
Rosuvastatin interactions may arise with other prescription drugs, other over-the-counter products, antacids, or even dietary supplements.
Tell your healthcare provider about all your current medications before taking rosuvastatin.
Unlike with some other statins, grapefruit is not a major drug interaction issue pointed out in the current prescribing information for Crestor in the USA.
Nevertheless, this does not imply that all foods, dietary supplements, or medicines are safe to take along with the prescribed rosuvastatin.
Make sure to always inform your healthcare provider of all the drugs and supplements you take. If you change to another statin, for example, atorvastatin, be sure to consult your pharmacist or doctor regarding any dietary restrictions concerning your new medicine.
There are no simple guidelines that state that alcohol cannot be taken in combination with rosuvastatin.
However, excessive consumption of alcohol affects the health of the liver, and rosuvastatin can also have negative impacts on the liver of the patient. The prescription states the possible development of hepatic dysfunction in such cases.
It is important for you to share the details of your alcohol consumption with your healthcare provider.
Key rosuvastatin interactions include:
Cyclosporine: Current FDA labeling indicates that Crestor must be restricted to 5mg once daily when taken with cyclosporine.
Aluminum and magnesium hydroxide antacids: You must take Crestor 2 hours prior to using these antacid products since they can interfere with absorption of rosuvastatin.
Warfarin: It is known that Crestor can influence INR. Prescribing information suggests getting the patient’s INR tested before taking Crestor and regularly monitoring INR until stable while beginning, altering, or stopping the drug.
The list of interactions is not comprehensive. Always consult with your pharmacist or physician prior to using this drug in combination with any other medicines.
Crestor should be stored at controlled room temperature between 68°F and 77°F (20°C and 25°C).
Storage instructions for Crestor:
Original packing
Free from excess moisture
Free from excess heat
Keep away from the reach of children and animals
Expired or unused drugs should be disposed of according to proper medication disposal procedures.
Crestor and Lipitor are often compared because they are statins but have different active ingredients.
Crestor contains rosuvastatin, whereas Lipitor contains atorvastatin.
Both drugs lower LDL cholesterol through the inhibition of HMG-CoA reductase, although they have differences in pharmacokinetics, metabolism, dosage, and interactions.
Feature | Crestor | Lipitor |
|---|---|---|
Brand name | Crestor | Lipitor |
Active ingredient | Rosuvastatin | Atorvastatin |
Drug class | Statin | Statin |
Adult labeled dosage range | 5 - 40 mg once daily | 10 - 80 mg once daily |
Food | With or without food | With or without food |
Dosing time | Any time of the day | Any time of the day |
Available strengths | 5 mg, 10 mg, 20 mg, 40 mg | 10 mg, 20 mg, 40 mg, 80 mg |
Neither of these medicines should be taken without consulting a doctor. Your healthcare professional chooses a statin and dose based on your LDL Cholesterol level, treatment objective, cardiovascular risk, medical history, liver and kidney considerations, other medications, and treatment response.
RxCroma makes prescription medication information and ordering service available online.
A valid prescription is mandatory to acquire prescription-only rosuvastatin. Only the prescribed strength of this medication must be ordered.
The price of Crestor and generic rosuvastatin may differ depending on the strength, quantity, brand name/generic form, manufacturer, availability, and pharmacy pricing.
If your prescription is for Crestor (rosuvastatin) 5 mg, you can review available branded and generic rosuvastatin options at RxCroma.
For a prescription specifying Crestor 10 mg, review current product information, availability, and pricing before making a purchase.
If your physician recommends Crestor 20 mg, you can compare available options through RxCroma.
Crestor is the brand name for rosuvastatin. The generic name for rosuvastatin is the same medication, just with different branding and at the same strength.
The cost difference between Crestor and generic rosuvastatin may be based on the pharmacy, manufacturer, amount of medication, and available discounts
If the prescription allows for generic substitution, the pharmacist can help determine if the generic is right for you.
If RxCroma offers any Crestor coupons, savings programs, promotional prices, or eligible discounts, all applicable offers will be displayed here.
🔺Note: Verification of coupon validity, qualifications, expiration, and applicable items must be done before the advertising campaign starts. Do not promote any available savings if the offer is already expired or has been discontinued.
🔺Important Safety Information
Crestor is a prescription drug. The content on this page is meant for educational use only and cannot replace the recommendation of a doctor or pharmacist.
Do not use Crestor if you have been told by a doctor that you should not take rosuvastatin, if you suffer from acute liver failure or decompensated cirrhosis, or if you have a known allergy to rosuvastatin or to any component of the product.
Inform your physician if you are pregnant, plan to become pregnant, breastfeed, have liver or kidney issues, or are using any other drugs, either prescription, over-the-counter, vitamin, or supplement.
Report to your healthcare provider immediately if you get unexplained muscle pain, tenderness, or weakness, especially if this problem is combined with fever or excessive fatigue.
Take Crestor always exactly as prescribed and according to the latest medication guide and prescribing information.
| Strength / pack | Price | Availability |
|---|---|---|
| 5mg | On request | Contact us |
| 10mg | On request | Contact us |
| 20mg | On request | Contact us |
| 40mg | On request | Contact us |
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